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Researcher:Assoc. Prof. Johannes Grillari
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Assoc. Prof. Johannes Grillari

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Assoc. Prof. Johannes GrillariResearcher


BOKU - University of Natural Resources and Life Sciences

Job title

Associate Professor
Aging and Immortalization Research


Ageing and Immortalization Research Group
Institute of Applied Microbiology
Muthgasse 18
1190 Vienna



Biology of Ageing / Biogerontology

Specialist areas

Replicative senescence
RNA biology
Endothelial and stem cells

Methodology areas

Cell culture techniques
Molecular biology techniques, protein biochemistry
Transcript profiling


Johannes Grillari, has more than 10 years of experience as a group leader in cellular and molecular ageing research. Since 2006 he is associate professor at the Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Austria. He did his PhD degree between 1996 and 1999 on senescence of endothelial cells and worked as a visiting scientist at the University of Dundee, Scotland, UK in the lab of Angus I. Lamond on the characterization of SNEV as a pre-mRNA splicing factor. He has authored and co-authored more than 35 scientific articles and book chapters, 4 patents, and was invited as speaker more than 30 times to international meetings.
During the last years his team has focused on the systematic identification and characterization of proteins and miRNAs that are differentially expressed in different cellular states and cell types with special emphasis on human endothelial cell senescence (ECs). Senescent ECs have been identified in vivo and are under suspicion to contribute to age related vascular diseases. Thus, cataloguing of genes and proteins that are differentially expressed and secreted in senescent ECs derived from human umbilical veins and the subsequent characterization of their biochemical and physiological roles in regulation of cell behaviour will give mechanistic insights into the process of aging, of the pathogeneses associated with aging like atherosclerosis and cancer and certainly will improve our understanding of replicative senescence in vitro per se.