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Researcher:Dr. Shai Shoham
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Dr. Shai Shoham

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Dr. Shai ShohamResearcher

Organisation

Herzog Hospital

Job title

Research Associate

Address

96 Givat Shaul Street
PO Box 3900
Jerusalem 91035
Israel

Disciplines

Biology of Ageing / Biogerontology, Psychology

Specialist areas

Neurodegenerative disorders associated with aging
Nutritional neuroscience of aging
Alcoholism and aging

Methodology areas

Immunohistochemistry
Neuroanatomical analysis
Correlation between behaviour and neuroanatomical analysis

Biography

My undergraduate education was in the department of Psychology at Haifa University in Israel. Graduate training was at the department of Psychology at the University of Illinois at Champaign-Urbana in the United States of America. The context of the research during my PhD and post-doctoral training was sleep physiology. My first post-doctoral training began at the University of Health Sciences/Chicago Medical School, Department of Physiology and Biophysics and continued at the Department of Physiology, University of Tennessee at Memphis. My second post-doctoral training was at the University of Cambridge, England. In this post-doctoral training I acquired the methodology of transplantation of nerve cells in animal models of aging-related neurodegenerative disorders. After setting up a research laboratory at the Herzog Hospital in Jerusalem, Israel, I investigated the effects of transplantation of nerve cells to various locations in the brain in an animal model of Alzheimer’s disease. I also developed an interest in the mechanisms that contribute to neurodegeneration and focused on the role of iron in oxidative stress in neurodegenerative processes activated by glutamatergic neurotransmission. My research has shown that reduction of dietary iron protected rats from glutamate analog-induced damage to the hippocampus. This research also led to my interest in the protective effects of dietary restriction and how dietary restriction protects the brain from effects of aging. One of the aspects of aging, namely, stress has attracted my attention and I have collaborated with Prof. Hermona Soreq from the Department of Biological Chemistry of the Hebrew University in Jerusalem on the effects of various types of stress on the brain in the context of aging and in other contexts. I have also collaborated with Prof. Marta Weinstock-Rosin looking at neuroprotective effects of a novel drug that combines anti-cholinesterase activity and mono-amine oxidase B inhibition in several models of aging.